CAS 1405-10-3 Neomycin Sulphate Pharmaceutical Raw Materials High
Purity White Powder
Chemical Formula : C23H48N6O17S
Molecular weight 712.7222
CAS No. : 1405-10-3
Quality 908 (Da)
Hydrogen bond donor : 13
Hydrogen bond acceptor number : 19
heavy atoms : 42
the complexity : 872
Properties: The product is white or off-white powder; odorless; wet
easily lead; right optical solution significantly. The product is
highly soluble in water, ethanol, ether, acetone or chloroform,
Category: antibiotic medicines.
Storage: sealed and kept in a dry place.
Neomycin sulfate is an aminoglycoside antibiotic. The product of
staphylococci (methicillin-susceptible strains), Enterobacteriaceae
bacteria Corynebacterium, Escherichia coli, Klebsiella, Proteus
have a good antibacterial effect on each group Streptococcus
pneumoniae chain aureus, Enterococcus and other active poor.
Pseudomonas aeruginosa, anaerobic bacteria resistant to the
chemicals. Bacteria to streptomycin, neomycin and kanamycin,
gentamicin between partial or complete cross-resistance. Neomycin
systemic administration have significant nephrotoxicity and
ototoxicity, it is currently limited to oral or topical
Neomycin is typically used as a topical preparation, such as
Neosporin. It can also be given orally, where it is usually
combined with other antibiotics. Neomycin is not absorbed from the
gastrointestinal tract and has been used as a preventive measure
for hepatic encephalopathy and hypercholesterolemia. By killing
bacteria in the intestinal tract, it keeps ammonia levels low and
prevents hepatic encephalopathy, especially prior to GI surgery. It
has also been used to treat small intestinal bacterial overgrowth.
It is not given intravenously, as neomycin is extremely nephrotoxic
(causes kidney damage), especially compared to other
aminoglycosides. The exception is when neomycin is included, in
very small quantities, as a preservative in some vaccines -
typically 0.025 mg per dose.
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